TxDOT has adopted the aspirational target, referred to as Road to Zero of zero traffic fatalities on Texas roadways by 2050. A variety of approaches are being taken to facilitate the potential reduction of fatal crashes and improve the overall safety for all road users. The application of proven safety countermeasures is key to reaching the Road to Zero target. One of the objectives of this manual is to promote safe-by-design practices by integrating safety analysis during project development, analyzing existing safety conditions, comparing alternatives, and predicting safety performance for future conditions. This manual also promotes consistency and standardization in safety analysis across the State and advances general transportation safety knowledge. Each District prepares annual safety plans to improve safety within their District.